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The norepinephrine pathway originates from the locus ceruleus (LC) and related brainstem nuclei; the serotonergic neurons originate from the raphe nuclei within the brainstem as nicely; the dopaminergic neurons originate in ventral tegmental area (VTA); and the histaminergic pathway originates from neurons within the tuberomammillary nucleus (TMN) of the posterior hypothalamus.

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The neurons of the histaminergic system are within the tuberomammillary nucleus of the hypothalamus.

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